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Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.

Coombes, Brandon J (author)
Millischer, Vincent (author)
Karolinska Institutet
Batzler, Anthony (author)
show more...
Larrabee, Beth (author)
Hou, Liping (author)
Papiol, Sergi (author)
Heilbronner, Urs (author)
Adli, Mazda (author)
Akiyama, Kazufumi (author)
Akula, Nirmala (author)
Amare, Azmeraw T (author)
Ardau, Raffaella (author)
Arias, Barbara (author)
Aubry, Jean-Michel (author)
Backlund, Lena (author)
Karolinska Institutet
Bauer, Michael (author)
Baune, Bernhard T (author)
Bellivier, Frank (author)
Benabarre, Antoni (author)
Bengesser, Susanne (author)
Bhattacharjee, Abesh Kumar (author)
Cervantes, Pablo (author)
Chen, Hsi-Chung (author)
Chillotti, Caterina (author)
Karolinska Institutet
Cichon, Sven (author)
Clark, Scott R (author)
Colom, Francesc (author)
Cruceanu, Cristiana (author)
Czerski, Piotr M (author)
Dalkner, Nina (author)
Degenhardt, Franziska (author)
Del Zompo, Maria (author)
DePaulo, J Raymond (author)
Étain, Bruno (author)
Falkai, Peter (author)
Ferensztajn-Rochowiak, Ewa (author)
Forstner, Andreas J (author)
Frisen, Louise (author)
Karolinska Institutet
Gard, Sébastien (author)
Garnham, Julie S (author)
Goes, Fernando S (author)
Grigoroiu-Serbanescu, Maria (author)
Grof, Paul (author)
Hashimoto, Ryota (author)
Hauser, Joanna (author)
Herms, Stefan (author)
Hoffmann, Per (author)
Jamain, Stephane (author)
Jiménez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kato, Tadafumi (author)
Kelsoe, John R (author)
Kittel-Schneider, Sarah (author)
König, Barbara (author)
Kuo, Po-Hsiu (author)
Kusumi, Ichiro (author)
Laje, Gonzalo (author)
Landén, Mikael, 1966 (author)
Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Lavebratt, Catharina (author)
Leboyer, Marion (author)
Leckband, Susan G (author)
Maj, Mario (author)
Karolinska Institutet
Manchia, Mirko (author)
Martinsson, Lina (author)
Karolinska Institutet
McCarthy, Michael J (author)
McElroy, Susan L (author)
Mitchell, Philip B (author)
Mitjans, Marina (author)
Mondimore, Francis M (author)
Monteleone, Palmiero (author)
Nievergelt, Caroline M (author)
Nöthen, Markus M (author)
Novák, Tomas (author)
O'Donovan, Claire (author)
Osby, Urban (author)
Ozaki, Norio (author)
Pfennig, Andrea (author)
Pisanu, Claudia (author)
Potash, James B (author)
Reif, Andreas (author)
Reininghaus, Eva (author)
Rietschel, Marcella (author)
Rouleau, Guy A (author)
Rybakowski, Janusz K (author)
Schalling, Martin (author)
Schofield, Peter R (author)
Schubert, Klaus Oliver (author)
Schweizer, Barbara W (author)
Severino, Giovanni (author)
Shekhtman, Tatyana (author)
Shilling, Paul D (author)
Shimoda, Katzutaka (author)
Simhandl, Christian (author)
Slaney, Claire M (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Tortorella, Alfonso (author)
Turecki, Gustavo (author)
Vieta, Eduard (author)
Witt, Stephanie H (author)
Zandi, Peter P (author)
Fullerton, Janice M (author)
Alda, Martin (author)
Frye, Mark A (author)
Schulze, Thomas G (author)
McMahon, Francis J (author)
Biernacka, Joanna M (author)
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 (creator_code:org_t)
2021-11-18
2021
English.
In: Complex psychiatry. - : S. Karger AG. - 2673-3005 .- 2673-298X. ; 7:3-4, s. 80-89
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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By the author/editor
Coombes, Brandon ...
Millischer, Vinc ...
Batzler, Anthony
Larrabee, Beth
Hou, Liping
Papiol, Sergi
show more...
Heilbronner, Urs
Adli, Mazda
Akiyama, Kazufum ...
Akula, Nirmala
Amare, Azmeraw T
Ardau, Raffaella
Arias, Barbara
Aubry, Jean-Mich ...
Backlund, Lena
Bauer, Michael
Baune, Bernhard ...
Bellivier, Frank
Benabarre, Anton ...
Bengesser, Susan ...
Bhattacharjee, A ...
Cervantes, Pablo
Chen, Hsi-Chung
Chillotti, Cater ...
Cichon, Sven
Clark, Scott R
Colom, Francesc
Cruceanu, Cristi ...
Czerski, Piotr M
Dalkner, Nina
Degenhardt, Fran ...
Del Zompo, Maria
DePaulo, J Raymo ...
Étain, Bruno
Falkai, Peter
Ferensztajn-Roch ...
Forstner, Andrea ...
Frisen, Louise
Gard, Sébastien
Garnham, Julie S
Goes, Fernando S
Grigoroiu-Serban ...
Grof, Paul
Hashimoto, Ryota
Hauser, Joanna
Herms, Stefan
Hoffmann, Per
Jamain, Stephane
Jiménez, Esther
Kahn, Jean-Pierr ...
Kassem, Layla
Kato, Tadafumi
Kelsoe, John R
Kittel-Schneider ...
König, Barbara
Kuo, Po-Hsiu
Kusumi, Ichiro
Laje, Gonzalo
Landén, Mikael, ...
Lavebratt, Catha ...
Leboyer, Marion
Leckband, Susan ...
Maj, Mario
Manchia, Mirko
Martinsson, Lina
McCarthy, Michae ...
McElroy, Susan L
Mitchell, Philip ...
Mitjans, Marina
Mondimore, Franc ...
Monteleone, Palm ...
Nievergelt, Caro ...
Nöthen, Markus M
Novák, Tomas
O'Donovan, Clair ...
Osby, Urban
Ozaki, Norio
Pfennig, Andrea
Pisanu, Claudia
Potash, James B
Reif, Andreas
Reininghaus, Eva
Rietschel, Marce ...
Rouleau, Guy A
Rybakowski, Janu ...
Schalling, Marti ...
Schofield, Peter ...
Schubert, Klaus ...
Schweizer, Barba ...
Severino, Giovan ...
Shekhtman, Tatya ...
Shilling, Paul D
Shimoda, Katzuta ...
Simhandl, Christ ...
Slaney, Claire M
Squassina, Aless ...
Stamm, Thomas
Stopkova, Pavla
Tortorella, Alfo ...
Turecki, Gustavo
Vieta, Eduard
Witt, Stephanie ...
Zandi, Peter P
Fullerton, Janic ...
Alda, Martin
Frye, Mark A
Schulze, Thomas ...
McMahon, Francis ...
Biernacka, Joann ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
Complex psychiat ...
By the university
University of Gothenburg
Karolinska Institutet

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